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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NME2
All Species:
46.06
Human Site:
Y151
Identified Species:
77.94
UniProt:
P22392
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22392
NP_001018146.1
152
17298
Y151
S
C
A
H
D
W
V
Y
E
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001147407
308
33377
Y307
S
C
A
H
D
W
V
Y
E
_
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001096144
240
26905
Y239
S
C
A
Q
N
W
I
Y
E
_
_
_
_
_
_
Dog
Lupus familis
XP_533973
152
17223
Y151
S
C
A
Q
N
W
I
Y
E
_
_
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q01768
152
17345
Y151
S
C
A
H
D
W
V
Y
E
_
_
_
_
_
_
Rat
Rattus norvegicus
P19804
152
17264
Y151
S
C
A
H
D
W
V
Y
E
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515701
267
30034
Y266
S
C
A
H
D
W
I
Y
E
_
_
_
_
_
_
Chicken
Gallus gallus
O57535
153
17269
Y152
S
C
A
H
D
W
V
Y
E
_
_
_
_
_
_
Frog
Xenopus laevis
P70011
154
17484
Y152
S
C
A
Y
E
W
V
Y
E
N
_
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_571001
153
17215
Y152
S
C
A
Q
Q
W
I
Y
E
_
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08879
153
17151
Y152
P
A
A
K
D
W
I
Y
E
_
_
_
_
_
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LAH8
237
25755
Y234
S
N
A
E
K
W
I
Y
G
Q
N
_
_
_
_
Baker's Yeast
Sacchar. cerevisiae
P36010
153
17148
Y152
S
N
Q
A
K
W
I
Y
E
_
_
_
_
_
_
Red Bread Mold
Neurospora crassa
Q9UUY8
152
16882
F151
H
H
S
A
A
W
I
F
E
_
_
_
_
_
_
Conservation
Percent
Protein Identity:
100
46.4
57
84.8
N.A.
98
98
N.A.
54.3
91.5
86.3
86.9
N.A.
77.1
N.A.
N.A.
N.A.
Protein Similarity:
100
47.7
60.8
92.1
N.A.
99.3
99.3
N.A.
55.8
96
94.8
92.8
N.A.
86.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
66.6
66.6
N.A.
100
100
N.A.
88.8
100
70
66.6
N.A.
55.5
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
88.8
88.8
N.A.
100
100
N.A.
100
100
90
77.7
N.A.
66.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
60.1
63.1
Protein Similarity:
N.A.
N.A.
N.A.
51
79
79.6
P-Site Identity:
N.A.
N.A.
N.A.
36.3
44.4
22.2
P-Site Similarity:
N.A.
N.A.
N.A.
45.4
55.5
55.5
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
86
15
8
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
72
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
50
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
8
0
0
0
93
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
8
8
0
43
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
58
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
15
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
15
0
0
0
0
8
8
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
22
8
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
86
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
43
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
86
93
100
100
100
100
% _